The soluble urokinase plasminogen activator receptor (suPAR) is a protein released during immune activation. suPAR reflects the body's inflammatory state, making it a universal and stable marker of overall health. Elevated suPAR levels are linked to chronic inflammation, which increases the risk of conditions like cardiovascular disease, kidney disease, and even mortality. Monitoring your suPAR score gives you insights into your health and helps guide proactive changes.

Indicator of Immune Activation: suPAR is released during immune system activation and inflammation. It reflects the body's immune response, particularly in conditions of stress, injury, and chronic inflammation.

Chronic Inflammation and Disease Prediction: Higher levels of suPAR are associated with chronic inflammation, immune dysfunction, and aging. It has been linked to various health conditions including cardiovascular diseases, diabetes, cancers, and overall mortality risk.

Stable Biomarker: Unlike some other inflammatory markers, suPAR levels remain stable over time, making it a reliable indicator for assessing long-term health risks rather than short-term fluctuations.

Predictive Value: Studies have shown that suPAR can predict disease outcomes and mortality more accurately than traditional biomarkers like CRP (C-reactive protein).

Lifestyle Influences: suPAR levels are responsive to lifestyle factors, such as diet and exercise, and can serve as an early warning sign for health deterioration.

By measuring the level of chronic inflammation in your body, suPAR provides insights into your biological age and your risk of developing diseases.

A high suPAR level indicates the presence of underlying inflammation, which may reflect an ongoing health issue requiring further evaluation. This may indicates that your current lifestyle is negatively impacting your body. To reduce the risk of future illness, it is recommended to initiate preventive measures and consider lifestyle changes.

A low suPAR level reflects minimal chronic inflammation, indicating optimal overall health and a very low risk of chronic diseases in the future if you maintain your current lifestyle.

The suPAR test stands out as a superior biomarker for predicting biological age and inflammation due to its unique ability to reflect chronic immune activation throughout the body. Unlike other biomarkers that typically capture acute reactions or are specific to certain diseases, suPAR provides a broader, more systemic perspective of an individual's overall health status.

Furthermore, suPAR remains stable in the bloodstream, offering consistent and reliable readings, which is important for tracking changes over time and assessing the impact of interventions.

Inflammation poses several significant health risks as it progresses with age. This persistent inflammatory state is linked to a range of age-related diseases and conditions.

Cardiovascular Diseases: Inflammation is strongly associated with the development of atherosclerosis, hypertension, and heart failure. The continuous inflammatory response contributes to the deterioration of cardiovascular health, increasing the risk of heart attacks and strokes.

Neurodegenerative Disorders: Inflammation in the central nervous system, particularly through the activation of microglia, plays a critical role in the progression of Alzheimer's and Parkinson's diseases. This neuroinflammation exacerbates neuronal damage and cognitive decline.

Diabetes: Chronic inflammation can impair insulin sensitivity and beta-cell function, leading to type 2 diabetes. Inflammation-driven cellular damage also complicates diabetes management and increases the severity of its complications.

Cancer: Inflammation can promote oncogenesis by creating an environment that supports tumor growth, angiogenesis, and metastasis. It also impairs the immune system’s ability to detect and destroy cancer cells.

Osteoporosis: Inflammatory cytokines can lead to bone resorption and decreased bone density, increasing the risk of fractures and osteoporosis.

Autoimmune Disorders: Enhanced inflammatory response may trigger or worsen autoimmune conditions such as rheumatoid arthritis and lupus, where the immune system mistakenly attacks healthy tissues.

Sarcopenia: The loss of muscle mass and strength, often seen in older adults, can be accelerated by chronic inflammation, affecting mobility and overall quality of life.

Respiratory Diseases: Chronic respiratory conditions such as COPD and asthma can be aggravated by ongoing inflammation, leading to more severe respiratory dysfunction and decreased lung capacity.

Biological age is a calculation that provides an estimate of how “old” your body is based on the level of chronic inflammation, as reflected by your suPAR result.

Unlike your chronological age, biological age is not a fixed number, and it is not a clinical diagnosis. Instead, it is a tool to support risk understanding and motivation for preventive health actions. A higher biological age may reflect a higher risk of developing disease or experiencing earlier functional decline.

The biological age estimate - also known as the InflammAge algorithm - is based on data from over 10,000 healthy individuals, combined with a large and growing database of real-world suPAR results. It compares your result to population-based trends in inflammation and disease risk.

This estimate is always a statistical approximation - many factors including genetics, lifestyle, temporary illness, or underlying conditions can influence your result. It should be interpreted in context and used as a starting point for deeper conversations about health, prevention and well-being.

Biological age refers to how old your body seems based on its physical and health condition, rather than the number of years you've been alive. It's determined by various factors like fitness level and overall health.

Epigenetic age is a bit more complex. It reflects changes in your body that occur over your lifetime due to environmental factors like exposure to toxins, and your genetic background. These changes affect how your genes are expressed, primarily through a process called DNA methylation.

While your biological age can show your current health status, your epigenetic age provides a deeper history of what your body has gone through over your lifetime.

The suPAR test gives you a quick look at where your health stands now, but your epigenetic age tells a longer story of the environmental and genetic influences you've experienced.

You can access your suPAR profile at clinic.eu.supar.health. Simply click the Log in button, enter your email address, and you’ll receive a login link directly in your inbox.

Once your results are ready, you’ll receive an email with a link to log in to your suPAR profile.

You can book a suPAR Health test at aetas.dk, or by contacting your nearest clinic that offers the suPAR test.

To get tested for suPAR, simply provide a blood sample at one of our certified partner clinics. Your sample will then be analyzed in our laboratory, and the results will be available in your profile within 7 days.

After laboratory analysis, the ordering clinic will receive your suPAR test result in approximately 7 days and release it to your personal suPAR Dashboard.

suPAR levels tend to decrease as inflammation in the body is reduced. Improvements may begin within weeks - for example, smoking cessation has been shown to lower suPAR by approximately 1 ng/mL in just four weeks. However, the rate of decline varies depending on the underlying cause, and in some cases, it may take months to observe meaningful changes. For most individuals, long-term tracking provides a more reliable picture than short-term fluctuations.

Green Score: Indicates good immune health, low inflammation, and a low risk of chronic disease. Suggests a healthy lifestyle and aging process.

Yellow Score: Reflects early signs of inflammation or stress, often linked to lifestyle factors like poor sleep, diet, or smoking. Signals a need for preventive action.

Orange Score: Suggests increased inflammation and potential underlying health issues. May indicate early disease activity or persistent lifestyle-related strain.

Red Score: Indicates significant immune activation and elevated disease risk. Common in individuals with chronic illness or ongoing health deterioration. Requires follow-up.

Regardless of the test result, you'll gain meaningful insights into your health status, enabling you to adjust your lifestyle accordingly.

Making a few key lifestyle adjustments can have a noticeable impact on your suPAR score.

Quit smoking: Quitting smoking can reduce your suPAR by an average of 1.0 ng/ml, with changes detectable in as little as 4 weeks.

Exercise: Regular exercise can lower your suPAR by up to 0.4 ng/ml. For individuals with a BMI over 35, losing weight can further reduce your levels by up to 0.5 ng/ml.

Diet: Eating a varied and healthy diet can help lower your suPAR by up to 0.3 ng/ml.

Sleep: Prioritizing good sleep quality and ensuring adequate rest can positively impact your suPAR levels.

Stress management: Managing stress through activities like meditation, breathing exercises, or nature walks can reduce suPAR by around 0.3 ng/ml.

Reduce alcohol intake: Excessive alcohol consumption raises inflammation and can increase suPAR. While the impact of moderate drinking is still being researched, minimizing alcohol intake is beneficial.

While these are some of the most straightforward ways to reduce your suPAR score, it’s important to note that if your result is high despite following these interventions, you should always consider the possibility of an underlying health condition. Consistently high suPAR levels can indicate an increased disease risk, so it's important to consult a doctor to rule out any underlying medical conditions.

Fine-tuning your lifestyle can lead to significant improvements in your suPAR score, but if lifestyle changes alone aren’t enough, personalized health interventions or treatment plans might be necessary. These can help identify the specific reasons behind elevated levels, ensuring that you address the root cause and further optimize your health.

For more in-depth information about each lifestyle intervention, visit the "How to improve your score" page in your suPAR profile.

The recommended frequency for suPAR testing depends on your current health status, clinical goals, and risk factors.

Preventive Health and General Screening

Recommendation: Every 6–12 months

For people undergoing annual health checks or seeking preventive insights, testing once or twice per year provides a stable indicator of low-grade inflammation and long-term health risk. This interval is sufficient to detect meaningful changes.

Lifestyle Intervention and Risk Reduction Monitoring

Recommendation: Every 3-6 months

For people actively working on improving lifestyle (e.g., smoking cessation, weight loss, stress reduction), or following specific interventions, suPAR can help track inflammation changes over time. A 3-6 month interval supports motivation and timely course corrections.

Chronic Disease Management or Elevated suPAR Levels

Recommendation: Every 1-2 months or as clinically indicated

People with persistently high suPAR levels or known chronic conditions may benefit from more frequent monitoring. This helps assess disease progression, treatment response, and immune system activity.

Acute Symptoms or Unexplained Inflammation

Recommendation: Case-by-case basis

In cases with acute symptoms, elevated CRP, or unexplained fatigue, suPAR may be used alongside other markers. Repeat testing may be considered after resolution or stabilization to assess residual inflammatory activity.

suPAR testing is supported by over 1,000 peer-reviewed studies and has been used in millions of tests worldwide. It meets CE-IVD standards in Europe and is in the process of obtaining FDA approval in the U.S.

suPAR is clinically validated for predicting disease risk and mortality, making it a trusted tool for long-term health monitoring. While GlycanAge focuses on immune aging, suPAR provides a more comprehensive and clinically proven assessment of overall health risks.

suPAR measures levels of soluble urokinase plasminogen activator receptor, reflecting systemic inflammation and immune system activity. This marker provides insight into overall health risks and potential disease progression, capturing a broad picture of inflammation across the body.

Other aging tests, such as those measuring TNF-a or IL-6, also assess inflammation but focus on different types or sources of inflammation within the body. While these markers provide valuable information on localized or specific inflammatory responses, suPAR offers a more comprehensive view of the body’s overall inflammatory state and its potential impact on health and aging.

suPAR is a clinically validated biomarker discovered in Denmark that has been extensively researched for over 20 years and utilized in more than 1,000,000 tests. The broad support from research across diverse populations confirms suPAR's reliability as a tool for predicting critical health outcomes, including mortality and chronic disease risk. For a detailed look at the supporting scientific papers, please visit our Clinical Studies page to learn more about how the test has been developed and validated.

The suPAR Health test is FDA approved for educational purposes only. It is designed to be used as a learning tool and should not be used for diagnostic or treatment decisions without professional medical advice.

RUO stands for Research Use Only. It means the test or device is intended strictly for scientific or exploratory use, and is not approved for clinical diagnostic or treatment decisions. In this context, RUO-marked tests can be used to generate biological insights or for monitoring in wellness and preventive settings, but the results should be interpreted carefully and are not to replace clinical judgment.

CE IVD stands for Conformité Européenne - In Vitro Diagnostic. It means that the test complies with EU regulations for diagnostic medical devices and is approved for clinical use in Europe. A CE IVD label ensures that the test has been assessed for safety, reliability, and clinical performance when used as intended, including diagnosis and monitoring of disease.

For questions about your suPAR result or general information about the test, please refer to the provided FAQ or contact your test provider.